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In Strenuously Working Muscle the PH Decreases

Question 43

Multiple Choice

In strenuously working muscle the pH decreases.This inhibits the activity of PFK-1 and glycolysis slows.Why would it be desirable to slow glycolysis when the demand for ATP is high?


A) Inhibition of PFK-1 allows for the complete oxidation of pyruvate via the citric acid cycle.
B) Slowing glycolysis slows the rate of decrease in pH.A low pH can be harmful and potentially fatal.
C) The less active form of PFK-1 is a potent allosteric activator of creatine,so even though glycolysis is slowed,ATP production is actually increased by the activation of creatine.
D) As PFK-1 is inhibited,its isozyme,PFK-2 is activated.PFK-2 is functional at a much lower pH than PFK-1.

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