The order of prosthetic groups as they act in the three proteins of the PDHpyruvate dehydrogenase) complex is: A) FAD → thiamine pyrophosphate → NAD⁺ B) FAD → thiamine pyrophosphate → dihydrolipoamide C) thiamine pyrophosphate → dihydrolipoamide → FAD D) NAD⁺→ FAD → dihydrolipoamide

Question

Quizplus · Accepted Answer

Thiamine pyrophosphate (TPP) acts first in the E1 enzyme, followed by dihydrolipoamide in E2, and finally FAD in E3 of the pyruvate dehydrogenase complex.

The Order of Prosthetic Groups as They Act in the Three