The stereoselective introduction of the C15 OH group on the w side chain of prostaglandins has presented a challenge for synthetic chemists.Recently, Mulzer and co-workers demonstrated a new route in which the wside chain is synthesized independently and then attached to the bicyclic counterpart.What is the appropriate sequence of reagents for the following synthesis?

Question

<sup> </sup>The stereoselective introduction of the C15 OH group on the w side chain of prostaglandins has presented a challenge for synthetic chemists.Recently, Mulzer and co-workers demonstrated a new route in which the wside chain is synthesized independently and then attached to the bicyclic counterpart.What is the appropriate sequence of reagents for the following synthesis? A) (1) PBr<sub>3</sub>; (2) Grubbs' catalyst, Reagent X; (3) KOC(CH<sub>3</sub>) <sub>3</sub> B) (1) PCC; (2) Ph<sub>3</sub>P=CH<sub>2</sub>; (3) Grubbs' catalyst, Reagent X C) (1) PBr<sub>3</sub>; (2) Ph<sub>3</sub>P=CH<sub>2</sub>; (3) Grubbs' catalyst, Reagent X D) (1) TsCl, pyridine; (2) Grubbs' catalyst, Reagent X; (3) KOC(CH<sub>3</sub>) <sub>3</sub>

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The Answer of The stereoselective introduction of the C15 OH group on the w side chain of prostaglandins has presented a challenge for synthetic chemists.Recently, Mulzer and co-workers demonstrated a new route in which the wside chain is synthesized independently and then attached to the bicyclic counterpart.What is the appropriate sequence of reagents for the following synthesis?

The Stereoselective Introduction of the C15 OH Group on the W