What is the reagent required to accomplish the following transformation?

Question

Quizplus · Accepted Answer

The transformation involves conversion of an aldehyde to a carboxylic acid while lengthening the carbon chain by one carbon. This can be achieved through oxidative cleavage of an alkene to a ketone followed by a Grignard reaction with carbon dioxide to give the carboxylic acid. Option B provides the necessary reagents for both these steps. [1] Oxidative cleavage of the alkene can be achieved using OsO4 and NaHSO3. [2] The resulting ketone can be treated with a Grignard reagent (NaHCO3) followed by carbon dioxide to give the carboxylic acid.

What Is the Reagent Required to Accomplish the Following Transformation