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Why Does Proline Not Give a Positive Test with Ninhydrin

Question 11

Multiple Choice

Why does proline not give a positive test with ninhydrin?


A) The secondary amine of proline is too weak a nucleophile to add to ninhydrin.
B) The Why does proline not give a positive test with ninhydrin? A)  The secondary amine of proline is too weak a nucleophile to add to ninhydrin. B)  The   of the ammonium in proline (10.6)  is too high to react with ninhydrin. C)  Hydrolysis of the second imine in the reaction mechanism cannot occur with proline. D)  The first imine cannot form in the reaction between proline and ninhydrin. E)  The second imine formed by decarboxylation in the mechanism is too unstable to form. of the ammonium in proline (10.6) is too high to react with ninhydrin.
C) Hydrolysis of the second imine in the reaction mechanism cannot occur with proline.
D) The first imine cannot form in the reaction between proline and ninhydrin.
E) The second imine formed by decarboxylation in the mechanism is too unstable to form.

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