The Vaginal Microbiome Changes as a Female Matures Because _______

The vaginal microbiome changes as a female matures because _______.

A) most sexually mature women use douching as a means to eliminate the vaginal microbiome
B) episodic treatments with antibiotics for UTIs and antifungals for vaginitis eliminate many of the normal microbiota
C) hormonal changes and sexual activity alter the environment of the vagina
D) estrogen has an antibiotic effect on the vaginal microbiome