According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5, 2013), transsexuals, who are experiencing extreme distress as a consequence of their gender variance, would be diagnosed with

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The DSM-5 defines Gender dysphoria as the distress or discomfort experienced by individuals whose gender identity differs from their assigned sex at birth. It is not a paraphilia or sexual dysfunction, nor is it classified as a dissociative disorder. As such, those experiencing extreme distress as a consequence of their gender variance would be diagnosed with gender dysphoria.