The Focus on Neuroscience on mapping brain changes in Alzheimer's disease summarized a study that discovered that the disease first attacks the thick bundle of axons called the corpus callosum, which is the main communication link between the two hemispheres.

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The study summarized in the Focus on Neuroscience did not specifically state that Alzheimer's disease first attacks the corpus callosum. Alzheimer's typically affects areas like the hippocampus and cortex first.

The Focus on Neuroscience on Mapping Brain Changes in Alzheimer's