If not treated with a special diet, which of the following leads to mental retardation?

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Phenylketonuria (PKU) is an inherited metabolic disorder in which the body cannot metabolize the amino acid Phenylalanine. If left untreated, it can lead to the accumulation of toxic chemicals in the brain, causing mental retardation, seizures, and other neurological problems. A special diet low in phenylalanine can prevent these complications. Hemophilia is a genetic disorder in which the blood does not clot properly, leading to excessive bleeding. Sickle-cell anemia is a genetic blood disorder that affects the shape of red blood cells, leading to anemia and pain. Down syndrome is a genetic disorder that causes intellectual disability and developmental delays. While a special diet may be helpful for individuals with Down Syndrome, it is not necessary to prevent mental retardation.

If Not Treated with a Special Diet, Which of the Following