Which of the Following Statements Is TRUE Regarding Off-Label Use

Which of the following statements is TRUE regarding off-label use of a drug?

A) More than half of off-label prescriptions are made with ample evidence supporting such use.
B) It occurs most often when doctors err in prescribing a drug.
C) It occurs when a drug is approved by Health Canada for one purpose and then prescribed for purposes not listed on the label.
D) Forty percent of medications used for off-label use result in adverse reactions to the patient.