What events lead to a differentiating B cell becoming committed to producing only one species of antibody molecule?
A)protein rearrangements in the genome
B)RNA rearrangements in the genome
C)DNA rearrangements in the genome
D)DNA rearrangements in the mitochondrion
E)spontaneous production of proteins in the Golgi complex

Question

Quizplus · Accepted Answer

Differentiation of B cells involves somatic recombination of genetic elements that encode for the variable regions of the antibody molecule. This process, known as V(D)J recombination, involves DNA rearrangements in the genome to generate a unique combination of V, D, and J gene segments. The specific combination of gene segments that are brought together determines the specificity of the B cell receptor, which eventually leads to the production of a single species of antibody molecule. Therefore, option C (DNA rearrangements in the genome) is the correct answer.

What Events Lead to a Differentiating B Cell Becoming Committed