You are studying a weasel and find that its genome contains 7 J_κ and 55 V_κ genes. Other sources of variation (such as changes in the site at which a J sequence joins a V sequence and the ability of deoxynucleotidyl transferase to insert nucleotides at sites of strand breakage)have been found to introduce an additional ten-fold increase in variability. Assuming that any V sequence can join with any J sequence, how many different κ light chains can this organism make? A)620 B)385 C)3850 D)70 E)550

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Quizplus · Accepted Answer

3850The organism can make 7 J_κ genes join with 55 V_κ genes, resulting in 7 * 55 = 385 different combinations. With the additional ten-fold increase in variability due to other sources, the total number of different κ light chains becomes 385 * 10 = 3850.

You Are Studying a Weasel and Find That Its Genome