How is class switching accomplished?
A)by mutation of the CH gene next to the VDJ gene that was formed previously by DNA rearrangement
B)by moving a different CH gene next to the VDJ gene that was formed previously by DNA rearrangement
C)by inversion of the CH gene next to the VDJ gene that was formed previously by DNA rearrangement
D)by duplicating the CH gene next to the VDJ gene that was formed previously by DNA rearrangement
E)by moving a different CH gene next to the VDJ gene that was formed previously by DNA mutation

Question

Quizplus · Accepted Answer

Class switching is accomplished by moving a different CH gene next to the VDJ gene that was formed previously by DNA rearrangement. This process, known as recombination, allows a B cell to switch from producing one type of antibody, with one type of constant region (CH), to another type with a different CH region. This allows the B cell to produce antibodies with different effector functions while retaining the same antigen specificity. The process of class switching involves the deletion of the intervening DNA segments between the VDJ and the new CH gene, which results in the loss of the previous CH region and the acquisition of a new one.

How Is Class Switching Accomplished