Under what circumstances are tumor cells likely to undergo apoptosis when they have sustained damage to DNA?

Question

Quizplus · Accepted Answer

The TP53 gene is known as the "guardian of the genome" and is responsible for detecting and repairing damaged DNA. If the damage is too severe, TP53 can trigger apoptosis in order to prevent the damaged cells from replicating and potentially forming tumors. Therefore, tumor cells with a functioning TP53 gene are more likely to undergo apoptosis in response to DNA damage.

Under What Circumstances Are Tumor Cells Likely to Undergo Apoptosis