Why Is the Use of Angiogenesis Inhibitors Less Likely to Stimulate

Why is the use of angiogenesis inhibitors less likely to stimulate the development of resistance when used to treat cancers?

A) Angiogenesis inhibitors target normal, genetically stable, endothelial cells, which continue to respond to the presence of these agents.
B) Angiogenesis inhibitors have low affinity for blood vessels.
C) Angiogenesis inhibitors are unstable and do not survive long enough to induce resistance.
D) Angiogenesis inhibitors are stable and survive too long to induce resistance.