How is signaling by an activated G_α subunit terminated? A)The bound GTP is hydrolyzed to GMP. B)The bound GDP is hydrolyzed to GTP. C)The bound GTP is hydrolyzed to GDP. D)The bound GDP is phosphorylated to GTP. E)The G_α subunit releases GDP and binds GTP.

Question

Quizplus · Accepted Answer

When the G_α subunit is activated, it exchanges GDP for GTP. To terminate the signaling, the bound GTP must be hydrolyzed to GDP. This typically occurs when an intrinsic GTPase activity within the alpha subunit catalyzes the hydrolysis of GTP to GDP, which restores the inactive GDP-bound state of the alpha subunit and allows it to re-associate with the beta and gamma subunits.

How Is Signaling by an Activated Gα Subunit Terminated

How Is Signaling by an Activated G_α Subunit Terminated