How is caspase-activated DNase (CAD)activated?
A)A caspase cleaves CAD, activating it.
B)A caspase cleaves an activator of CAD, turning it on and causing it to activate CAD.
C)A caspase cleaves a CAD inhibitor, relieving the CAD of inhibition.
D)A caspase binds to CAD allosterically, activating it.
E)None of these are correct.

Question

Quizplus · Accepted Answer

CAD is a nuclease that is activated by cleavage of its inhibitor ICAD by caspases. This cleavage leads to the release of the active CAD enzyme, which is then able to cleave chromosomal DNA during apoptosis.

How Is Caspase-Activated DNase (CAD)activated