Which Piece of Evidence Provided the Best Evidence That the Sequence

Which piece of evidence provided the best evidence that the sequence of DNA itself was unimportant in the timing of replication?

A) The inactive, heterochromatized X chromosome in female mammals replicates late in S phase, while the active euchromatic X chromosome replicates at an earlier stage.
B) The inactive, heterochromatized X chromosome in female mammals replicates early in S phase, while the active euchromatic X chromosome replicates at a later stage.
C) The inactive, heterochromatized X chromosome in female mammals replicates late in M phase, while the active euchromatic X chromosome replicates at an earlier stage.
D) Incorporation of radioactive DNA precursors in replicating cells begins over heterochromatic regions in the nucleus.
E) Incorporation of radioactive DNA precursors in replicating cells ends over heterochromatic regions in the nucleus.