In the transcription-coupled repair pathway of nucleotide excision repair, how is the presence of a lesion thought to be detected?
A)There are special enzymes that scan the DNA for such lesions.
B)The lesion may be signaled by a stalled RNA polymerase.
C)The lesion may be signaled by a stalled DNA polymerase.
D)The lesion may be signaled by a stalled peptidyl transferase.
E)The lesion may be detected single-stranded binding proteins.

Question

Quizplus · Accepted Answer

In the transcription-coupled repair pathway, the presence of a lesion is thought to be detected by a stalled RNA polymerase. When RNA polymerase encounters a lesion in the template strand, it stalls due to its inability to incorporate new nucleotides. This stall triggers the recruitment of repair proteins to the site of the lesion.

In the Transcription-Coupled Repair Pathway of Nucleotide Excision Repair, How