What experimental evidence suggests that the N-terminal tails of histones participate in the formation of higher-order chromatin structure?
A)The tails cause histones to denature.
B)The tails when acetylated cause the dissolution of the 30-nm fibers.
C)Chromatin fibers with histones lacking their tails cannot fold into higher-order fibers.
D)Chromatin fibers with histones possessing longer tails cannot fold into higher-order fibers.
E)Chromatin fibers lacking tails are shorter.

Question

Quizplus · Accepted Answer

Experimental evidence suggests that chromatin fibers with histones lacking their tails cannot fold into higher-order fibers. For example, studies with reconstituted chromatin fibers have shown that histone tails are required for the formation of the 30-nm fiber and higher-order chromatin structure. In addition, deletion of the N-terminal tails of histones in vivo leads to alterations in chromatin structure and gene expression.

What Experimental Evidence Suggests That the N-Terminal Tails of Histones