Why would changes in the genes for transcription factors be expected to generate major phenotypic differences?

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Transcription factors are proteins that bind to DNA and regulate the transcription (expression) of other genes. Changes in the genes that encode transcription factors can affect the expression of large numbers of other genes due to their regulatory role. This can have a major impact on phenotype, as the expression of different genes can lead to differences in cellular processes, developmental pathways, and ultimately, observable traits.

Why Would Changes in the Genes for Transcription Factors Be