What does the conformation-sensing enzyme UGGT do if it binds to a misfolded or incompletely folded glycoprotein?
A)It degrades the oligosaccharide chain.
B)It adds a single mannose back to one of the glucose residues at the exposed end of the recently trimmed oligosaccharide.
C)It adds a single glucose back to one of the mannose residues at the exposed end of the recently trimmed oligosaccharide.
D)It degrades the protein.
E)It refolds the protein on its own.

Question

Quizplus · Accepted Answer

UGGT adds a single glucose back to one of the mannose residues at the exposed end of the recently trimmed oligosaccharide on misfolded or incompletely folded glycoproteins, which signals that the protein needs more time in the ER for proper folding.

What Does the Conformation-Sensing Enzyme UGGT Do If It Binds