You coat a Petri dish with fibronectin and proteoglycans and then culture cells on the dish. The cells adhere to the dish. You repeat the experiment but this time add RGD tripeptides to the culture dish as the cells are added. What happens?
A)The cells adhere as they normally do.
B)The cells die immediately.
C)The cells lyse immediately.
D)The cells do not adhere to the dish.
E)The cells immediately change their phenotype.

Question

Quizplus · Accepted Answer

RGD tripeptides are known to inhibit cell adhesion by competing with fibronectin for binding to integrins on the cell surface. Therefore, if RGD tripeptides are added to the culture dish, the cells will not be able to bind to the fibronectin-coated dish and will not adhere.

You Coat a Petri Dish with Fibronectin and Proteoglycans and Then