In focal adhesion, large clusters of integrins bond to which component via various adaptors?
A)tubulins of the cytoskeleton
B)myosin of the cytoskeleton
C)actin of the cytoskeleton
D)dynein of the cytoskeleton
E)band III protein of the membrane

Question

Quizplus · Accepted Answer

Focal adhesions are composed of large clusters of integrins that bind to the actin filaments of the cytoskeleton via various adaptors. The integrins act as transmembrane receptors, connecting the extracellular matrix to the intracellular cytoskeleton, and allowing the cell to sense and respond to mechanical forces. Therefore, integrin-actin interactions are critical for the regulation of cell adhesion, migration, and signaling.

In Focal Adhesion, Large Clusters of Integrins Bond to Which