What kind of interaction is NOT involved in the binding of a substrate to a normally functioning enzyme?

Question

Quizplus · Accepted Answer

A permanent covalent bond is not involved in the binding of a substrate to a normally functioning enzyme. Enzyme-substrate binding is typically a reversible process, with non-covalent interactions such as hydrogen bonds, ionic bonds, and hydrophobic interactions being primarily responsible for substrate binding. Transient covalent bonds, such as those formed in some enzyme-catalyzed reactions, are not involved in the initial binding of substrate to enzyme.

What Kind of Interaction Is NOT Involved in the Binding