2-[¹⁸F] fluoro-2-deoxy-D-glucose (FDG)accumulates within tumor cells engaging in higher than normal glycolytic activity. Which reactive functional group is missing in FDG, permitting its accumulation in tumor cells and their detection through PET scans?

Question

Quizplus · Accepted Answer

FDG is a modified form of glucose with the hydroxyl group on the C2 carbon replaced by a radioactive fluorine atom. This modification ensures that FDG is not further metabolized by the cell, allowing it to accumulate within tumor cells with high glycolytic activity. Therefore, the missing functional group in FDG is a hydroxyl group.

2-[18F] Fluoro-2-Deoxy-D-Glucose (FDG)accumulates Within Tumor Cells Engaging in Higher Than

2-[¹⁸F] Fluoro-2-Deoxy-D-Glucose (FDG)accumulates Within Tumor Cells Engaging in Higher Than