Why should pMDIs containing steroids in particular be used with a valved holding chamber?

Question

Quizplus · Accepted Answer

Valved holding chambers reduce the pharyngeal dose of aerosol from the pMDI 10- to 15-fold over administration without a holding chamber. Using a valved holding chamber decreases total body dose from swallowed medications, which is an important consideration with steroid administration. The high percentage of oropharyngeal drug deposition with steroid pMDIs can increase the risk of oral yeast infections (thrush). Rinsing the mouth after steroid inhalation can reduce this problem, but most pMDI steroid aerosol impaction occurs deeper in the pharynx, which is not easily rinsed. For this reason, steroid pMDIs should always be used in combination with a valved holding chamber.

Why Should PMDIs Containing Steroids in Particular Be Used with a Valved