An inhibitor of which of the following could be used to block the release of calcium from the endoplasmic reticulum?
A) tyrosine kinases
B) serine/threonine kinases
C) phosphodiesterase
D) phospholipase C
E) adenylyl cyclase

Question

Quizplus · Accepted Answer

Phospholipase C is an enzyme that cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which then leads to the release of Ca2+ from the endoplasmic reticulum. Therefore, an inhibitor of phospholipase C could block the release of calcium from the endoplasmic reticulum.

An Inhibitor of Which of the Following Could Be Used