A plant-derived protein known as colchicine can be used to poison cells by blocking the formation of the spindle. Which of the following would result if colchicine is added to a sample of cells in G₂?

Question

Quizplus · Accepted Answer

In G₂ phase, the chromosomes have already duplicated and are coiled and condensed in preparation for mitosis. If colchicine is added, the formation of the spindle is blocked, and the chromosomes cannot attach to it. Therefore, the chromosomes would coil and shorten but have no spindle to which to attach. The cells would be unable to progress through mitosis and divide, resulting in cell death.

A Plant-Derived Protein Known as Colchicine Can Be Used to Poison