Cells from an advanced malignant tumor most often have very abnormal chromosomes, and often an abnormal total number of chromosomes. Why might this occur?
A) Cancer cells are no longer density dependent.
B) Cancer cells are no longer anchorage dependent.
C) Chromosomally abnormal cells can still go through cell cycle checkpoints.
D) Chromosomally abnormal cells still have normal metabolism.
E) Transformation introduces new chromosomes into cells.

Question

Quizplus · Accepted Answer

Chromosomally abnormal cells often have mutations in genes involved in cell cycle checkpoints, which allows them to bypass these checkpoints and continue to divide despite the abnormalities.

Answer: E
 Transformation, which is the process by which cells become cancerous, involves the introduction of new genes or the activation of dormant genes that can lead to abnormal chromosome numbers and structures. This can result in cells with an abnormal total number of chromosomes.

Cells from an Advanced Malignant Tumor Most Often Have Very