Why do histones bind tightly to DNA?
A) Histones are positively charged, and DNA is negatively charged.
B) Histones are negatively charged, and DNA is positively charged.
C) Both histones and DNA are strongly hydrophobic.
D) Histones are covalently linked to the DNA.
E) Histones are highly hydrophobic, and DNA is hydrophilic.

Question

Quizplus · Accepted Answer

Histones are positively charged due to the presence of many basic amino acids such as lysine and arginine, while DNA is negatively charged due to the presence of phosphate groups in its backbone. The electrostatic attraction between the positively charged histones and negatively charged DNA leads to tight binding.

Why Do Histones Bind Tightly to DNA