Which of the following mutations is most likely to cause a phenotypic change?
A) a duplication of all or most introns
B) a large inversion whose ends are each in intergenic regions
C) a nucleotide substitution in an exon coding for a transmembrane domain
D) a single nucleotide deletion in an exon coding for an active site
E) a frameshift mutation one codon away from the 3' end of the nontemplate strand

Question

Quizplus · Accepted Answer

A single nucleotide deletion in an exon coding for an active site is most likely to cause a phenotypic change because it can directly affect the protein's function by altering its active site, potentially leading to a loss or change in function.

Which of the Following Mutations Is Most Likely to Cause