A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture.
-In one set of experiments using this procedure in Drosophila, she was readily successful in increasing phosphorylation of amino acids adjacent to methylated amino acids in histone tails. Which of the following results would she most likely see?
A) increased chromatin condensation
B) decreased chromatin condensation
C) abnormalities of mouse embryos
D) decreased binding of transcription factors
E) inactivation of the selected genes

Question

Quizplus · Accepted Answer

Increased phosphorylation of amino acids adjacent to methylated amino acids in histone tails generally leads to decreased chromatin condensation. This is because phosphorylation adds negative charges to the histone tails, which can weaken the interaction between the histones and the DNA, leading to a more open chromatin structure that is accessible for transcription.

A Researcher Found a Method She Could Use to Manipulate