Testicular feminization syndrome is unlikely to occur if the
A) SRY gene expression is downregulated
B) production of Müllerian-inhibiting substance is inhibited in a male embryo
C) testosterone and dihydrotestosterone receptors are present and functional
D) enzyme 5 α-reductase is blocked
E) production of estrogens and progesterone is adequate

Question

Quizplus · Accepted Answer

Testicular feminization syndrome occurs when there is a lack of response to testosterone and dihydrotestosterone, which are necessary for male sexual differentiation. Therefore, if the receptors for these hormones are present and functional (Choice C), the syndrome is unlikely to occur. The other choices are not directly related to the development of the syndrome.

Testicular Feminization Syndrome Is Unlikely to Occur If the