The hormone primarily responsible for the regulation of water loss is

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Vasopressin, also known as antidiuretic hormone (ADH), is primarily responsible for the regulation of water loss. It is produced in the hypothalamus and released by the pituitary gland in response to an increase in the concentration of solutes in the blood or a decrease in blood volume. Vasopressin acts on the kidneys to increase reabsorption of water, which leads to a decrease in urine output and a conservation of body water.

The Hormone Primarily Responsible for the Regulation of Water Loss