What is a difference between the processing of an endogenous antigen and an exogenous antigen?
A) one uses major histocompatibility complex I (MHC-I) proteins, and the other uses major histocompatibility complex II (MHC-II) proteins
B) one involves fragmentation of antigenic proteins, and the other involves fusion of peptide fragments to form antigenic proteins
C) one takes place exclusively in the lymph nodes, and the other takes place exclusively inside a body cell
D) one involves synthesis of major histocompatibility complex (MHC) proteins at the endoplasmic reticulum, and the other involves synthesis of major histocompatibility complex (MHC) proteins in the cytoplasm
E) one involves exocytosis of the antigen-major histocompatibility complex (MHC) protein compound, and the other involves diapedesis of the antigen-MHC compound

Question

Quizplus · Accepted Answer

Endogenous antigens are processed using major histocompatibility complex I (MHC-I) proteins, while exogenous antigens are processed using major histocompatibility complex II (MHC-II) proteins. MHC-I proteins are found on the surface of all nucleated cells and present peptides from intracellular proteins to CD8+ T cells, while MHC-II proteins are found on the surface of specialized antigen-presenting cells (such as macrophages and dendritic cells) and present peptides from extracellular proteins to CD4+ T cells.

What Is a Difference Between the Processing of an Endogenous