$\beta$ adrenergic receptors that bind epinephrine and initiate fight or flight response are arguably the most talked about G protein coupled receptors. They act through increasing levels of cAMP in the target cell. Which of the following would block the actions of the $\beta$ adrenergic receptor?
A) depleting GTP in the cell
B) blocking receptor translocation to the nucleus
C) blocking protein kinase C
D) depleting phosphatidylinositol bisphosphate in the cell

Question

Quizplus · Accepted Answer

Depleting GTP in the cell would block the actions of the adrenergic receptor because G protein-coupled receptors (like the adrenergic receptors) require GTP to activate the G protein, which then initiates the downstream signaling cascade, including the increase of cAMP levels.

β\betaβ Adrenergic Receptors That Bind Epinephrine and Initiate Fight or Flight

$\beta$ Adrenergic Receptors That Bind Epinephrine and Initiate Fight or Flight