Which Is the Best Description of Insulin Resistance

Which is the best description of insulin resistance?

A) The pancreas fails to produce insulin due to damage to alpha cells.
B) The pancreas produces insulin but fails to secrete a sufficient amount when blood glucose is high.
C) The pancreas secretes insulin, it is ineffective because body cells are insensitive to it action.
D) The pancreas secretes glucagon instead of insulin in response to high blood glucose.