What is the principle that indicates that after about 50 doublings, cells lose their ability to replicate?

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The principle that indicates that after about 50 doublings, cells lose their ability to replicate is known as the Hayflick limit, named after the researcher who discovered it, Dr. Leonard Hayflick. This phenomenon represents a natural limit to the replication capacity of normal cells, and it is mediated by the shortening of telomeres, the protective caps at the ends of chromosomes. As cells divide, telomeres get progressively shorter until they trigger a growth arrest mechanism known as senescence, which prevents the cells from dividing further. This limit is thought to be a protective mechanism against cancer, which can arise from uncontrolled cell division.

What Is the Principle That Indicates That After About 50