How does malonyl-CoA inhibit the -oxidation of a fatty acid?

Question

Quizplus · Accepted Answer

Malonyl-CoA inhibits the transport of fatty acids across the mitochondrial membrane by inhibiting the enzyme carnitine acyltransferase, which is necessary for fatty acid transport into the mitochondria for β-oxidation. This prevents the oxidation of fatty acids and favors the synthesis and storage of fatty acids. Malonyl-CoA does not affect the activity of acetyl-CoA synthase.

How Does Malonyl-CoA Inhibit the -Oxidation of a Fatty Acid