Which of the following must occur so that the pre-initiation complex can be converted to the open complex?
A) The C terminal end of the RNA polymerase must be dephosphorylated.
B) The C terminal end of the RNA polymerase must be phosphorylated.
C) The N terminal end of the RNA polymerase must be dephosphorylated.
D) The N terminal end of the RNA polymerase must be phosphorylated.

Question

Quizplus · Accepted Answer

The conversion of the pre-initiation complex to the open complex requires the phosphorylation of the C-terminal end of the RNA polymerase. This phosphorylation causes a conformational change in the RNA polymerase, allowing it to unwind the DNA double helix and form the transcription bubble.

Which of the Following Must Occur So That the Pre-Initiation