At which pH does a protein have the lowest solubility?
A) at a very low pH
B) at a neutral pH of 7
C) at a very high pH
D) at its isoelectric point

Question

Quizplus · Accepted Answer

The isoelectric point is the pH at which a protein has a net charge of zero. At this pH, the protein has the lowest solubility because the charges on the protein balance out, reducing the electrostatic repulsion between protein molecules and allowing them to form aggregates that precipitate out of solution.

At Which PH Does a Protein Have the Lowest Solubility