Identify the disease that is caused by conformational change in the α-helical content of the normal prion protein.

Question

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All three diseases (mad cow, scrapie, and Creutzfeld-Jakob) are caused by conformational changes in the normal prion protein, resulting in the formation of abnormally folded prion proteins that can act as infectious agents. These diseases are all examples of prion diseases, also known as transmissible spongiform encephalopathies.

Identify the Disease That Is Caused by Conformational Change in the α-Helical