How does aspirin block the active site of cyclooxygenase enzymes?
A) by adding an acetyl group to the enzyme's active site
B) by adding a methyl group to the enzyme's active site
C) by removing an anhydride group from the enzyme's active site
D) by removing a carbonyl group from the enzyme's active site

Question

Quizplus · Accepted Answer

Aspirin works by irreversibly inhibiting the activity of cyclooxygenase enzymes by acetylating the active site of the enzyme. Specifically, aspirin acetylates a serine residue located at the active site of cyclooxygenase enzymes, which prevents the enzyme from functioning properly.

How Does Aspirin Block the Active Site of Cyclooxygenase Enzymes