(Video: The development of tangles and plaques in Alzheimer's disease) Neurons need long chains of molecules for their nourishment. TAU is a protein that keeps these chains stable. In Alzheimer's disease, the TAU

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In Alzheimer's disease, TAU proteins, which normally keep chains of molecules stable for neuron nourishment, start to curl and tangle, leading to the formation of neurofibrillary tangles.

(Video: the Development of Tangles and Plaques in Alzheimer's Disease)