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Chlorambucil Is a Chemotherapeutic Drug Used in the Treatment of Chronic

Question 9

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Chlorambucil is a chemotherapeutic drug used in the treatment of chronic lymphatic leukemia. It is a nitrogen mustard alkylating agent that can be given orally. The name "nitrogen mustards" stems from the group of alkylating military agents designed for chemical warfare that feature the N-(CH2) 2-Cl motif. Which DNA-base can be alkylated easily?(Hint: Which aromatic system has the highest electron density?)
Chlorambucil is a chemotherapeutic drug used in the treatment of chronic lymphatic leukemia. It is a nitrogen mustard alkylating agent that can be given orally. The name  nitrogen mustards  stems from the group of alkylating military agents designed for chemical warfare that feature the N-(CH<sub>2</sub>) <sub>2</sub>-Cl motif. Which DNA-base can be alkylated easily?(Hint: Which aromatic system has the highest electron density?)    A) Adenine B) Guanine C) Cytosine D) Thymine


A) Adenine
B) Guanine
C) Cytosine
D) Thymine

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