Isoleucine has pk_a values of 2.32 (-COOH) and 9.76 (-NH₃⁺). Which is isoleucine's isoelectric point?

Question

Quizplus · Accepted Answer

The isoelectric point (pI) is the pH at which the amino acid has no net charge. To determine the pI, we need to average the two pKa values (pk_a and pk₃⁺) that correspond to the two ionizable groups of the amino acid (carboxylic acid and amino groups). pI = (pKa1 + pKa2) / 2 pI = (2.32 + 9.76) / 2 pI = 6.04 Therefore, the answer is choice C.

Isoleucine Has Pka Values of 2

Isoleucine Has Pk_a Values of 2