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Urokinase-Type Plasminogen Activator (UPa) Is a Serine Endopeptidase

Question 29

Multiple Choice

Urokinase-type Plasminogen Activator (uPa) is a serine endopeptidase. The active site of this peptidase binds the peptide-motif Ser-Gly-Arg-Ser-Ala and cleaves the protein/peptide between arginine and serine. What is the sequence of the products of the oligopeptide
Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp
After cleavage by uPa?


A) Ala-Gly and Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp
B) Ala-Gly-Ser-Gly-Arg and Ser-Ala-Lys-Gly-Ala-Ser-Asp
C) Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser and Asp
D) Ala-Gly-Ser-Gly-Arg-Ser and Ala-Lys-Gly-Ala-Ser-Asp

Correct Answer:

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