Existing biocontainment strategies employ natural auxotrophies that are not easily met in natural, or conditional suicide switches introduced into the organism's genome. However, these mechanisms can be compromised through

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Existing biocontainment strategies can be compromised through genetic mutations, which could result in the development of resistance or loss of function in the auxotrophic or suicide switch systems. Synthetic auxotrophies, synthetic biology, logic gates, and genetic circuits can be used to enhance biocontainment, but they cannot overcome the potential effects of genetic mutations.

Existing Biocontainment Strategies Employ Natural Auxotrophies That Are Not Easily