RAG1 and RAG2 are enzymes that control gene splicing on B-cell antibody genes. Which order are segments worked on in the creation of the heavy-chain gene segment?
A) VD spliced together, then J, then C
B) DJ spliced together, then V
C) VJ spliced together, then D
D) VC spliced together, then D, then J
E) VDJ segments are all spliced together simultaneously.

Question

Quizplus · Accepted Answer

RAG1 and RAG2 enzymes first join the D and J segments, then the V segment is added to the DJ segment. This order is known as VDJ recombination and applies to the heavy-chain gene segment. Therefore, choice B is the correct order in which the segments are worked on in the creation of the heavy-chain gene segment.

RAG1 and RAG2 Are Enzymes That Control Gene Splicing on B-Cell